Protein Purification
MilliporeSigma™ Calbiochem™ CBFβ-Runx1 Inhibitor II, Ro5-3335
A cell-permeable benzodiazepine that suppresses CBFα/Runx1-CBFβ transactivation activity (25μM; 293-0 cells) via direct bindings to both subunits of the heterodimeric transcription factor complex
MilliporeSigma™ Calbiochem™ JmjC Histone Demethylase Inhibitor, n-Octyl-IOX1
A cell-permeable, superior inhibitor of Jumonji C domain histone lysine demethylase. About 30 fold more potent than IOX1 (EC50 = 3.8 μM for KDM4A in HeLa cells vs. 100 μM for IOX1).
MilliporeSigma™ Calbiochem™ InSolution™ Rac1 Inhibitor
The InSolution™ Rac1Inhibitor, also referenced under CAS 1177865-17-6, controls the biological activity of Rac1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ AhR Antagonist II, SR1
The AhR Antagonist II, SR1 controls the biological activity of AhR. This small molecule/inhibitor is primarily used for Biochemicals applications.
MilliporeSigma™ Calbiochem™ Adenosine A1 Receptor Agonist II, CCPA
An adenosine analog that acts as a selective, high affinity agonist for Adenosine A1 receptor (A1R) (Ki = 800 pM
MilliporeSigma™ Calbiochem™ InSolution™ 5-Aza-2'-Deoxycytidine
A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines.
MilliporeSigma™ Calbiochem™ Metformin
An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia.
MilliporeSigma™ Calbiochem™ NEMO-Binding Domain Binding Peptide, Cell-Permeable, Negative Control
A cell-permeable Antennapedia-NBD mutated fusion peptide analog of NEMO-Binding Domain Binding Peptide that serves as a negative control.
MilliporeSigma™ Calbiochem™ ICI 118551 Hydrochloride
A highly selective antagonist for the β2 adrenergic receptors
MilliporeSigma™ Calbiochem™ PI-103
A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR.
MilliporeSigma™ Calbiochem™ Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride
Inhibits trypsin-like serine proteinases.
MilliporeSigma™ Calbiochem™ D609, Potassium Salt
Selective inhibitor of phosphatidylcholine (PC)-specific phospholipase C (Ki = 5-10 μM).
MilliporeSigma™ Calbiochem™ AG 490
A cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC50 = 100 nM).
MilliporeSigma™ Calbiochem™ Caspase-4 Inhibitor I
The Caspase-4 Inhibitor I, also referenced under CAS 402832-01-3, controls the biological activity of Caspase-4. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ Carboplatin
An analog of Cisplatin with reduced nephrotoxicity. Displays potent antitumor activity.